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Correlation between infectious disease and soil radiation in Japan: an exploratory study using national sentinel surveillance data

From 16 January 2017
Summary
We investigated the relationship between epidemics and soil radiation through an exploratory study using sentinel surveillance data (individuals aged <20 years) during the last three epidemic seasons of influenza and norovirus in Japan. We used a spatial analysis method of a geographical information system (GIS). We mapped the epidemic spreading patterns from sentinel incidence rates. We calculated the average soil radiation [dm (μGy/h)] for each sentinel site using data on uranium, thorium, and potassium oxide in the soil and examined the incidence rate in units of 0·01 μGy/h. The correlations between the incidence rate and the average soil radiation were assessed. Epidemic clusters of influenza and norovirus infections were observed in areas with relatively high radiation exposure. A positive correlation was detected between the average incidence rate and radiation dose, at r = 0·61–0·84 (P < 0·01) for influenza infections and r = 0·61–0·72 (P < 0·01) for norovirus infections. An increase in the incidence rate was found between areas with radiation exposure of 0 < dm < 0·01 and 0·15 ⩽ dm < 0·16, at 1·80 [95% confidence interval (CI) 1·47–2·12] times higher for influenza infection and 2·07 (95% CI 1·53–2·61) times higher for norovirus infection. Our results suggest a potential association between decreased immunity and irradiation because of soil radiation. Further studies on immunity in these epidemic-prone areas are desirable.
References
1. Inaida S, et al. Geographic trends and spread of the pandemic (H1N1) 2009 in the metropolitan areas of Japan studied from the national sentinel data. Japanese Journal of Infectious Diseases 2011; 64: 473–481. Google Scholar | PubMed
2. Inaida S, et al. The south to north variation of norovirus epidemics from 2006–07 to 2008–09 in Japan. PLoS ONE 2013; 8: e71696. CrossRef | Google Scholar | PubMed
3. Inaida S, et al. The spatial diffusion of norovirus epidemics over three seasons in Tokyo. Epidemiology & Infection 2014; 143: 522–528. CrossRef | Google Scholar | PubMed
4. Shahid S, et al. Mutations of the human interferon alpha-2b (hIFNα − 2b) gene in low-dose natural terrestrial ionizing radiation exposed dwellers. Cytokine 2015; 76: 294–302. CrossRef | Google Scholar | PubMed
5. Shahid S, et al. Mutations of the human interferon alpha-2b (hIFN-α2b) gene in occupationally protracted low dose radiation exposed personnel. Cytokine 2015; 73: 181–189. CrossRef | Google Scholar | PubMed
6. Amagi T, et al. Dysfunction of irradiated thymus for the development of helper T cells. Journal of Immunology 1987; 139: 358–364. Google Scholar
7. Sajjadieh MRS, et al. Affects of ionizing radiation on T-cell population lymphocyte: a risk factor of irritable bowel syndrome. Toxicology and Industrial Health 2010; 6: 323–330. CrossRef | Google Scholar
8. Godekmerdan A, et al. Diminished cellular and humoral immunity in workers occupationally exposed to low levels of ionizing radiation. Archives of Medical Research 2004; 35: 324–328. CrossRef | Google Scholar | PubMed
9. Sajjadieh MRS, et al. Effect of ionizing radiation on development process of T-cell population lymphocytes in Chernobyl children. Iranian Journal of Radiation Research 2009; 7: 127–133. Google Scholar
10. Stewart AM, et al. Non-cancer effects of exposure to A-bomb radiation. Journal of Epidemiology & Community Health 1984; 38: 108–112. CrossRef | Google Scholar | PubMed
11. Stewart AM. Delayed effects of A-bomb radiation: a review of recent mortality rates and risk estimates for five-year Survivors. Journal of Epidemiology & Community Health 1982; 36: 80–86. CrossRef | Google Scholar | PubMed
12. Stewart AM, et al. A-bomb survivors: factors that may lead to a re-assessment of the radiation hazard. International Journal of Epidemiology 2000; 29: 708–714. CrossRef | Google Scholar | PubMed
13. Stewart AM, et al. Radiation and marrow damage. British Medical Journal (Clinical Research Edition) 1982; 284: 1192. CrossRef | Google Scholar | PubMed
14. Ohkita T. Acute effects. Journal of Radiation Research: 1975; 16 (Suppl. 1): 49–66. CrossRef | Google Scholar
15. Kusunoki Y, et al. Long-lasting alterations of the immune system by ionizing radiation exposure: implications for disease development among atomic bomb survivors. International Journal of Radiation Biology 2008; 84: 1–14. CrossRef | Google Scholar | PubMed
16. Wuttke K, et al. Radiation induced micronuclei in subpopulations of human lymphocytes. Mutation Research 1993; 2: 181–188. CrossRef | Google Scholar
17. Bauman A, et al. The impact of natural radioactivity from a coal-fired power plant. Science of the Total Environment 1981; 17: 75–81. CrossRef | Google Scholar | PubMed
18. Hagelstrom AH, et al. Chromosomal damage in workers occupationally exposed to chronic low level ionizing radiation. Toxicology Letters 1995; 76: 113–117. CrossRef | Google Scholar | PubMed
19. Pohl-Rüling J. Low level dose induced chromosome aberrations in human blood lymphocytes. Radiation Protection Dosimetry 2014; 159: 10–19. Google Scholar
20. Gricienė B, et al. Cytogenetic monitoring of nuclear workers occupationally exposed to ionising radiation. Radiation Protection Dosimetry 1992; 1–4: 623–627. Google Scholar
21. Jahns J, et al. Influence of low dose irradiation on differentiation, maturation and T-cell activation of human dendritic cells. Mutation Research 2011; 709–710: 32–39. CrossRef | Google Scholar | PubMed
22. McMahon DM, et al. Effects of long-term low-level radiation exposure after the Chernobyl catastrophe on immunoglobulins in children residing in contaminated areas: prospective and cross-sectional studies. Environmental Health 2014; 000: 13–36. Google Scholar
23. Oskouii MR, et al. Assessment of humoral immunity in workers occupationally exposed to low levels of ionizing radiation. Life Science Journal 2013; 5s. Google Scholar
24. Daniak N, et al. Hematologic consequences of exposure to ionizing radiation. Experimental Hematology 2002; 30: 513–528. CrossRef | Google Scholar
25. Beck HL, et al. In-situ Ge (Li) and NaI (Tl) gamma ray spectrometry. Health and Safety Laboratory AEC, Report HASL, 1972, pp. 258. Google Scholar
26. Infectious Agents Surveillance Report (IASR). Infectious Surveillance Centre, NIID, Japan (http://idsc.nih.go.jp/iasr/prompt/graph-ke.html). Google Scholar
27. Inaida S, et al. Delayed norovirus epidemic in the 2009–2010 season in Japan: potential relationship with intensive hand sanitizer use for pandemic influenza. Epidemiology & Infection 2016; 12: 2561–2567. CrossRef | Google Scholar
28. Motomura K, et al. Identification of monomorphic and divergent haplotypes in the 2006–2007 norovirus GII/4 epidemic population by genomewide tracing of evolutionary history. Journal of Virology 2008; 82: 11247–11262. CrossRef | Google Scholar | PubMed
29. Taniguchi K, et al. Overview of infectious disease surveillance system in Japan, 1999–2005. Journal of Epidemiology 2007; 17 (Suppl: S3 –1). CrossRef | Google Scholar
30. Michael R, et al. The use and interpretation of the Friedman test in the analysis of ordinal-scale data in repeated measures designs. Physiotherapy Research International 1996; 1: 221–228. Google Scholar
31. Ministry of Health, Labour and Welfare. Survey of medical institutions (http://www.mhlw.go.jp/english/database/db-hss/mi.html). Accessed 2 April 2015. Google Scholar
32. Geological Society of Japan. Radioactive elements in soil (2004) (https://gbank.gsj.jp/geochemmap/index_e.htm). Accessed 23 April 2014. Google Scholar
33. Minato S. Distribution of terrestrial γ ray dose rates in Japan. Journal of Geography 2006; 1: 87–95. CrossRef | Google Scholar
34. Watson DF. Contouring: a Guide to the Analysis and Display of Spatial Data. Oxford: Elsevier, 1992, pp. 321. Google Scholar
35. Sarmah K, et al. Land suitability analysis for identification of summer paddy cultivation sites based on multi criteria evaluation through GIS. European Academic Research 2015; 2: 13584–13606. Google Scholar
36. Ujeno Y. Carcinogenetic hazard from natural background radiation in Japan. The Journal of Radiation Research 1978; 19: 205–212. CrossRef | Google Scholar | PubMed
37. Land CE. Estimating cancer risks from low doses of ionizing radiation. Science 1980; 209: 1197–1203. CrossRef | Google Scholar
38. Rossi HH, et al. Radiation carcinogenesis at low doses. Science 1972; 175: 200–202. CrossRef | Google Scholar
39. Brenner DJ, et al. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proceedings of the National Academy of Sciences USA 2003; 100: 13761–13766. CrossRef | Google Scholar
40. Hodge FA, et al. Susceptibility to infection with Pasteurella tularensis and the immune response of mice exposed to continuous low dose rate gamma radiation. Journal of Infectious Diseases 1969; 120: 356–365. CrossRef | Google Scholar
41. Barcinski MA, et al. Cytogenetic investigation in a Brazilian population living in an area of high natural radioactivity. American Journal of Human Genetics 1975; 27: 802–806. Google Scholar
42. François A, et al. Inflammation and immunity in radiation damage to the gut mucosa. BioMed Research International 2013; 123 241. CrossRef | Google Scholar
43. Somosy Z, et al. Morphological aspects of ionizing radiation response of small intestine. Micron 2002; 33: 167–178. CrossRef | Google Scholar
44. Coia LR, et al. Late effects of radiation therapy on the gastrointestinal tract. International Journal of Radiation Oncology, Biology, Physics 1995; 31: 1213–1236. CrossRef | Google Scholar | PubMed
45. Siebenga JJ, et al. Epochal evolution of GGII.4 norovirus capsid proteins from 1995 to 2006. Journal of Virology 2007; 81: 9932–9941. CrossRef | Google Scholar | PubMed
46. Reber AJ, et al. Seasonal influenza vaccination of children induces humoral and cell-mediated immunity beyond the current season: cross-reactivity with past and future strains. Journal of Infectious Diseases 2016; 214: 1477–1486. CrossRef | Google Scholar | PubMed
47. Gloag D. Risks of low-level radiation – the evidence of epidemiology. British Medical Journal 1980; 281: 1479–1482. CrossRef | Google Scholar | PubMed
48. Land CE. Uncertainty, low-dose extrapolation and the threshold hypothesis. Journal of Radiological Protection 2002; 3A: A129–135. CrossRef | Google Scholar
 
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February 27, 2018 - Posted by | Fukushima 2018 | ,

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