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New fast test to detect ionising radiation

Scientists create a speedy finger-prick test to scan for radiation exposure in mice, Stat, By JULIET ISSELBACHERJULY 15, 2020  
Researchers have developed a simple finger-prick test that scans a single drop of blood to rapidly determine whether the body has been exposed to toxic levels of radiation.

Catastrophic radiological events — like nuclear detonations — can threaten massive populations with acute radiation syndrome, which wreaks havoc on the gastrointestinal system and destroys bone marrow, leading to infections and internal bleeding. In preparation for the possibility of such a public health disaster, scientists at Ohio State have devised a speedy and scalable method for estimating radiation exposure. They published their proof-of-concept research, conducted in mice, Wednesday in Science Translational Medicine.

Timing is key when it comes to assessing radiation dosage in members of an exposed population. Victims above a certain dose threshold require immediate and aggressive treatment, such as a blood transfusion or cytokine therapy.

“Early detection will save lives,” said Naduparambil Jacob, senior author of the study and a molecular biologist at Ohio State University Comprehensive Cancer Center.
The current “gold standard” test for radiation exposure is a dicentric chromosome assay, which looks for hallmarks of radiation-induced DNA damage. The problem is that this test takes around three or four days to yield results — a waiting period that can make it harder for clinicians to know how to proceed and can potentially jeopardize patient outcomes.
“If it takes you four days to get the result, then it’s not helpful in immediate management,” said C. Norman Coleman, a researcher at the National Cancer Institute who was not involved with the study. “The idea of getting some kind of number pretty quickly that tells you what you need to do is useful for the medical system and also for the patient.”

The test Jacob’s team developed has the capability to turn out a number within hours……….

July 15, 2020 - Posted by | radiation

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