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Increased breast cancer risk in ionising radiation

“Our work shows that radiation can change the microenvironment of breast cells, and this in turn can allow the growth of abnormal cells with a long-lived phenotype that has a much greater potential to be cancerous,”

Study Raises New Concerns About Radiation and Breast Cancer « Berkeley Lab News Center, 14 May 2010, “………It is well established that exposure to ionizing radiation can result in mutations or other genetic damage that cause cells to turn cancerous. Now a new study led by researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has revealed another way in which radiation can promote cancer development. Working with cultures of human breast cells, the researchers discovered that radiation exposure can alter the environment surrounding the cells so that future cells are more likely to become cancerous.“Our work shows that radiation can change the microenvironment of breast cells, and this in turn can allow the growth of abnormal cells with a long-lived phenotype that has a much greater potential to be cancerous,” says Paul Yaswen, a cell biologist and breast cancer research specialist with Berkeley Lab’s Life Sciences Division….

Yaswen is the corresponding author of a paper describing this study that appears in the on-line journal Breast Cancer Research, titled “Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies.” Co-authoring the paper were Rituparna Mukhopadhyay, Sylvain Costes, Alexey Bazarov, William Hines and Mary Helen Barcellos-Hoff…………
This study was jointly funded the National Institute of Environmental Health Sciences (NIEHS), and the National Cancer Institute (NCI), NIH, through the Bay Area Breast Cancer and the Environment Center, and by the NASA Specialized Center of Research.

Study Raises New Concerns About Radiation and Breast Cancer « Berkeley Lab News Center

May 14, 2010 - Posted by Christina Macpherson | health, USA | antinuclear, cancer, nuclear, radiation, radioactive