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Negotiators representing two-thirds of the 192-member United Nationsfinalized the 10-page treaty this week after months of talks.

The document, called the Treaty on the Prohibition of Nuclear Weapons, was formally adopted on Friday at United Nations headquarters in New York during the final session of the negotiation conference.

It will be open for signature by any member state starting on Sept. 20 during the annual General Assembly and would enter into legal force 90 days after being ratified by 50 countries. “The world has been waiting for this legal norm for 70 years,” said Elayne G. Whyte Gómez, Costa Rica’s ambassador to the United Nations in Geneva and chairwoman of the conference, which was broadcast live on the United Nations website.

Cheers and applause erupted among the delegates after the vote was tallied: 122 in favor and one against — the Netherlands, the only NATO member that participated in the conference. Singapore abstained.

The participants did not include any of the world’s nine nuclear-armed countries, which conspicuously boycotted the negotiations.

Some critics of the treaty, including the United States and its close Western allies, publicly rejected the entire effort, calling it misguided and reckless, particularly when North Korea is threatening a nuclear-tipped missile strike on American soil……. Disarmament groups and other proponents of the treaty said they had never expected that any nuclear-armed country would sign it — at least not at first. Rather, supporters hope, the treaty’s widespread acceptance elsewhere will eventually increase the public pressure and stigma of harboring and threatening to use such weapons of unspeakable destruction, and make holdouts reconsider their positions.

“This treaty is a strong categorical prohibition of nuclear weapons and is really rooted in humanitarian law,” said Beatrice Fihn, executive director of the International Campaign to Abolish Nuclear Weapons, a Geneva-based coalition of groups that advocated the treaty. “It provides a path for nuclear-armed states to join,” Ms. Fihn said in an interview on Thursday. “We don’t expect them to sign the treaty right now, but it’s a good starting point for changing perceptions.”

She and other supporters of the treaty contend that the coercive power of such an agreement can exert enormous influence on public and government opinion.

Treaties that banned biological and chemical arms, land mines and cluster bombs have shown how weapons once regarded as acceptable are now widely, if not universally, reviled. That is the kind of outcome sought by proponents of the nuclear ban pact. “While the treaty itself will not immediately eliminate any nuclear weapons, the treaty can, over time, further delegitimize nuclear weapons and strengthen the legal and political norm against their use,” said Daryl G. Kimball, executive director of the Arms Control Association, a Washington-based group that supports the treaty.

Nuclear weapons have defied attempts to contain their spread since the United States dropped two atomic bombs on Japan in 1945, ending World War II………

Mr. Kimball called the new treaty “an expression of the deep concern about the enormous risks posed by nuclear weapons and the growing frustration with the failure of the nuclear-armed states to fulfill their nuclear disarmament commitments.”

The new accord would outlaw nuclear weapons use, threat of use, testing, development, production, possession, transfer and stationing in a different country. For nuclear-armed nations that choose to join, the treaty outlines a process for destroying stockpiles and enforcing the countries’ promise to remain free of nuclear weapons.

The basic premise, the treaty’s opening passage states, is a recognition of “the catastrophic humanitarian consequences that would result from any use of nuclear weapons,” and an agreement that their complete elimination “remains the only way to guarantee that nuclear weapons are never used again under any circumstances.”