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https://en.wikipedia.org/wiki/Operation_Grapple

“Some human diseases caused by translocations are:
Cancer: Several forms of cancer are caused by acquired translocations (as opposed to those present from conception); this has been described mainly in leukemia (acute myelogenous leukemia and chronic myelogenous leukemia). Translocations have also been described in solid malignancies such as Ewing’s sarcoma.
Infertility: One of the would-be parents carries a balanced translocation, where the parent is asymptomatic but conceived fetuses are not viable.
Down syndrome is caused in a minority (5% or less) of cases by a Robertsonian translocation of the chromosome 21 long arm onto the long arm of chromosome 14.[5]
Chromosomal translocations between the sex chromosomes can also result in a number of genetic conditions, such as XX male syndrome: caused by a translocation of the SRY gene from the Y to the X chromosome…”
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“In 1938, Karl Sax, at the Harvard…